Title: Acute stress-induced colonic tissue HSP70 expression requires commensal bacterial components and intrinsic glucocorticoid
نویسندگان
چکیده
منابع مشابه
Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells.
In contrast to the negative autoregulation of glucocorticoid receptor (GR) expression seen in most cells and tissues, GR expression is positively autoregulated in human leukemic T cells and in other cells sensitive to glucocorticoid-induced cell death. To determine whether positive autoregulation is a necessary component of glucocorticoid-induced cell death, a wild-type GR gene under the contro...
متن کاملExpression of glucocorticoid resistance following social stress requires a second signal.
Stimulation of splenocytes from socially stressed mice [social disruption (SDR)] with Gram-negative bacterial lipopolysaccharide (LPS) revealed a state of functional glucocorticoid (GC) resistance. LPS-stimulated splenocytes were less sensitive to the inhibitory effects of corticosterone. This study demonstrated that activation signals were required for the expression of splenic GC resistance. ...
متن کاملEndoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.
Members of the caspase family are essential for many apoptotic programs. We studied mouse embryonic fibroblasts (MEFs) deficient in caspases 3 and 7 and in caspase 9 to determine the role of these proteases in endoplasmic reticulum (ER) stress-induced apoptosis. Both caspase 3(-/-)/caspase 7(-/-) and caspase 9(-/-) MEFs were resistant to cytotoxicity induced via ER stress and failed to exhibit ...
متن کاملEstrogen Attenuates Post-Exercise Hsp70 Expression in Skeletal Muscle Running Title: Sex-specific Hsp70 induction
Exercise has been demonstrated as a physiological inducer of Hsp70. Many of the factors associated with exercise proposed to signal this response demonstrate sexual dimorphism. Thus, the present objectives were to determine if Hsp70 induction following exercise exhibited gender-specificity and to elucidate the mechanisms underlying such a phenomenon. Post-exercise Hsp70 induction in skeletal mu...
متن کاملStress-induced Hsp70 gene expression and inactivation of Cryptosporidium parvum oocysts by chlorine-based oxidants.
Our research on the mechanisms of action of chlorine-based oxidants on Cryptosporidium parvum oocysts in water revealed a dual-phase effect: (i) response to oxidative stress, which was demonstrated by induced expression of the Hsp70 heat shock gene, and (ii) oocyst inactivation as a result of long-term exposure to oxidants. The relative biocidal effects of sodium hypochlorite (bleach) and elect...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Physical Fitness and Sports Medicine
سال: 2009
ISSN: 0039-906X,1881-4751
DOI: 10.7600/jspfsm.58.47